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Arsenal will check on Dani Ceballos, who missed Monday’s match against Newcastle with a tight calf. Pablo Mari is still recovering from a calf strain but should return to training next week. Gabriel Martinelli and Nicholas Pepe could feature.
N’Golo Kante could be back after hamstring trouble, while Timo Werner may start having been on the bench for Monday’s 2-0 loss at Leicester. Billy Gilmour could step into midfield, with the young Scot pushing hard for a start.
Tino Anjorin could be one of few academy youngsters to step into the matchday squad.
Dan Potts could start at centre-back for a Luton side looking for another big performance. However, Tom Lockyer’s red card appeal was successful and he is available for selection. Kal Naismith could step in at left-back to complete the reshuffle if required.
Aymeric Laporte and Eric Garcia are back in training but Sergio Aguero revealed on Thursday he is self-isolating after testing positive for coronavirus.
Cheltenham defender Chris Hussey is a doubt. The 32-year-old has been nursing a foot injury and was forced off in the first half of Tuesday’s 1-1 draw with Newport.
Andriy Yarmolenko, Pablo Fornals and Mark Noble are pushing for West Ham starts. Goalkeeper Darren Randolph deputised for Lukasz Fabianski at Stockport in the third round and could do so again. Ryan Fredericks, Ben Johnson, Fabián Balbuena and Issa Diop are also all fit and available.
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Doncaster could welcome defender Joe Wright back after he returned from injury as a substitute against Rochdale. However, Liam Ravenhill and James Coppinger – who turned 40 in the week – will miss out through injury, while Madger Gomes is back in training following a long-term hamstring injury.
Matt Doherty has an unspecified problem and Serge Aurier has been feeling unwell. Giovani Lo Celso is the only definite absentee with a hamstring problem. Mourinho has said he will rotate his team but will take a full-strength squad.